St. Jude scientists map how a DNA repair protein works
In short
- Scientists at St. Jude Children's Research Hospital uncovered a mechanism behind PARP1-mediated DNA repair.
- Inhibiting DNA damage repair can help in cancers with genetic vulnerabilities in DNA damage response.
- The results were published in Molecular Cell.
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The study explains how cells repair damaged DNA through a specific protein, PARP1. The source says this may have implications for cancer treatment, but it describes basic research and does not report a treatment or trial. Clinical use would require further work.
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From Phys.org
When DNA is damaged, cellular processes respond and repair the DNA. Inhibiting DNA damage repair can be therapeutically beneficial in cancers with genetic vulnerabilities related to DNA damage response. Scientists at St. Jude Children's Research Hospital have uncovered a mechanism behind how this process works, which may have implications for cancer treatment. The results were published today in Molecular Cell.
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